Inhibitors of Bacterial Tyrosyl tRNA Synthetase: Synthesis of Carbocyclic Analogues of the Natural Product SB-219383
Author/Authors :
Richard L. Jarvest، نويسنده , , John M. Berge، نويسنده , , Catherine S. V. Houge-Frydrych، نويسنده , , Lucy M. Mensah، نويسنده , , Peter J. OʹHanlon، نويسنده , , Andrew J. Pope، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
4
From page :
2499
To page :
2502
Abstract :
Carbocyclic analogues of the microbial metabolite SB-219383 have been synthesised and evaluated as inhibitors of bacterial tyrosyl tRNA synthetase. One compound showed highly potent and selective nanomolar inhibition.
