Title of article :
Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands
Author/Authors :
Silvia Schenone، نويسنده , , Olga Bruno، نويسنده , , Paola Fossa، نويسنده , , Angelo Ranise، نويسنده , , Giulia Menozzi، نويسنده , , Luisa Mosti، نويسنده , , Francesco Bondavalli، نويسنده , , Claudia Martini، نويسنده , , Maria Letizia Trincavelli، نويسنده ,
Abstract :
The synthesis of a new family of A1-adenosine receptor (A1AR) ligands 3a–n has been performed in a straightforward way. Affinity data at A1AR, A2AAR and A3AR in bovine membranes show that these new compounds bind the A1AR in a selective way over A2AAR and A3AR and one of them (3j) presents a very high affinity, probably due to the phenethylamine substituent at C-4.
