Title of article
Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1
Author/Authors
Adrian Folkes، نويسنده , , Michael B. Roe، نويسنده , , Sukhjit Sohal، نويسنده , , Julian Golec، نويسنده , , Richard Faint، نويسنده , , Teresa Brooks، نويسنده , , Peter Charlton، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2589
To page
2592
Abstract
We have synthesized and evaluated a series of diketopiperazine-based inhibitors of PAI-1. These studies resulted in the identification of 34 which inhibited PAI-1 in vitro with an IC50=0.2 μM. The synthesis and SAR of these compounds are described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791686
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