Title of article
Potent peptide α-Ketohydroxamate inhibitors of recombinant human calpain I
Author/Authors
Kurt A. Josef، نويسنده , , Frederick W. Kauer، نويسنده , , Ron Bihovsky، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2615
To page
2617
Abstract
A series of potent dipeptide and tripeptide α-ketohydroxamic esters was prepared as inhibitors of recombinant human calpain I. Compound 3c, a Cbz-Leu-Phe hydroxamate, displayed the greatest potency against calpain I (IC50=6 nM), while two compounds, 3l and 3m, both possessing the Cbz-Leu-Leu-Phe sequence, were the most potent (IC50=0.2 μM) in a MOLT-4 cell assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791692
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