Author/Authors :
Peter Wipf، نويسنده , , Tamara D. Hopkins، نويسنده , , Jae-Kyu Jung، نويسنده , , Sonia Rodriguez، نويسنده , , Anne Birmingham، نويسنده , , Eileen C. Southwick، نويسنده , , John S. Lazo، نويسنده , , Garth Powis and William R Montfort، نويسنده ,
Abstract :
Natural products of the naphthoquinone spiroketal structural type served as lead structures for the development of novel inhibitors of the thioredoxin–thioredoxin reductase redox system. The most potent compound in this series inhibited thioredoxin with an IC50 of 350 nM, and many derivatives showed low micromolar activities for growth inhibition against two breast cancer cell lines.
