Title of article
New inhibitors of the thioredoxin–thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead
Author/Authors
Peter Wipf، نويسنده , , Tamara D. Hopkins، نويسنده , , Jae-Kyu Jung، نويسنده , , Sonia Rodriguez، نويسنده , , Anne Birmingham، نويسنده , , Eileen C. Southwick، نويسنده , , John S. Lazo، نويسنده , , Garth Powis and William R Montfort، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2637
To page
2641
Abstract
Natural products of the naphthoquinone spiroketal structural type served as lead structures for the development of novel inhibitors of the thioredoxin–thioredoxin reductase redox system. The most potent compound in this series inhibited thioredoxin with an IC50 of 350 nM, and many derivatives showed low micromolar activities for growth inhibition against two breast cancer cell lines.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791697
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