Title of article
Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-Terpyridine derivatives
Author/Authors
Long-Xuan Zhao، نويسنده , , Tae Sung Kim، نويسنده , , Soo-Hyun Ahn، نويسنده , , Tae-Hyung Kim، نويسنده , , Eunkyung Kim، نويسنده , , Won-Jea Cho، نويسنده , , Heesung Choi، نويسنده , , Chong-Soon Lee، نويسنده , , Jung-Ae Kim، نويسنده , , Tae Cheon Jeong، نويسنده , , Ching-jer Chang، نويسنده , , Eung Seok Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2659
To page
2662
Abstract
For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure–activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791702
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