Title of article
Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase
Author/Authors
L. M. V. Tillekeratne، نويسنده , , A. Sherette، نويسنده , , Jordan P. Grossman، نويسنده , , L. Hupe، نويسنده , , D. Hupe، نويسنده , , R. A. Hudson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2763
To page
2767
Abstract
Systematic simplification of the molecular structures of epicatechin gallate and epigallocatechin gallate to determine the minimum structural characteristics necessary for HIV-1 reverse transcriptase inhibition in vitro resulted in several compounds that strongly inhibited the native as well as the A17 double mutant (K103N Y181C) enzyme, which is normally insensitive to most known nonnucleoside inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791725
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