Title of article
NaBH4 in N-methylpyrrolidone: a safe alternative for hydride displacement reaction
Author/Authors
Yasuhiro Torisawa، نويسنده , , Takao Nishi MD، نويسنده , , Jun-ichi Minamikawa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2787
To page
2789
Abstract
Enhanced reactivity of NaBH4 was observed as a solution in N-methylpyrrolidone (NMP). Thus, a simple protocol for debromination of alkyl bromide and sulfonate is devised with NMP as a key solvent. Also described is a new mixed borohydride system, NaBH4–LiOTf–NMP, which works as an alternative to NaBH3CN for the SN2 type displacement. No reports have ever revealed usefulness of NMP in borohydride reduction.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791730
Link To Document