Author/Authors :
Milo Sedl?k، نويسنده , , Vladim?r Buchta، نويسنده , , Lenka Kubicov?، نويسنده , , Petr im nek، نويسنده , , Michal Hol apek، نويسنده , , Pavla Ka parov?، نويسنده ,
Abstract :
The reaction of methoxypoly(ethylene glycol)-4-nitrophenyl carbonate with amphotericin B has been used to prepare a new conjugate of amphotericin B (mPEG-AmB). A preliminary screening of in vitro antifungal activity has suggested that mPEG-AmB posseses a similar effect and a similar spectrum of activity as the conventional amphotericin B formulated with sodium desoxycholate.
