Title of article
Design and synthesis of a novel class of histone deacetylase inhibitors
Author/Authors
Rico Lavoie، نويسنده , , Giliane Bouchain، نويسنده , , Sylvie Frechette، نويسنده , , Soon Hyung Woo، نويسنده , , Elie Abou Khalil، نويسنده , , Silvana Leit، نويسنده , , Marielle Fournel، نويسنده , , Pu T. Yan، نويسنده , , Marie-Claude Trachy-Bourget، نويسنده , , Carole Beaulieu، نويسنده , , Zuomei Li، نويسنده , , Jeffrey Besterman، نويسنده , , Daniel Delorme، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2847
To page
2850
Abstract
Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791743
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