Author/Authors :
Rico Lavoie، نويسنده , , Giliane Bouchain، نويسنده , , Sylvie Frechette، نويسنده , , Soon Hyung Woo، نويسنده , , Elie Abou Khalil، نويسنده , , Silvana Leit، نويسنده , , Marielle Fournel، نويسنده , , Pu T. Yan، نويسنده , , Marie-Claude Trachy-Bourget، نويسنده , , Carole Beaulieu، نويسنده , , Zuomei Li، نويسنده , , Jeffrey Besterman، نويسنده , , Daniel Delorme، نويسنده ,
Abstract :
Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities.
