Title of article
2-(Anilinomethyl)imidazolines as α1-adrenoceptor agonists: the identification of α1A subtype selective 2′-carboxylic acid esters and amides
Author/Authors
Michael J. Bishop، نويسنده , , Judd Berman، نويسنده , , Eric C. Bigham، نويسنده , , Deanna T. Garrison، نويسنده , , Michael J. Gobel، نويسنده , , Stephen J. Hodson، نويسنده , , Paul E. Irving، نويسنده , , James A. Liacos، نويسنده , , Douglas J. Minick، نويسنده , , Frank Navas، نويسنده , , David L. Saussy Jr.، نويسنده , , Jason D. Speake، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2871
To page
2874
Abstract
2-(Anilinomethyl)imidazolines with 2′-esters or 2′-amides are potent agonists of the cloned human α1-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. α1A-subtype selective agonists have been identified.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791749
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