Author/Authors :
Fujie Tanaka، نويسنده , , Lisa Kerwin، نويسنده , , Diane Kubitz، نويسنده , , Richard A. Lerner، نويسنده , , Carlos F. Barbas III، نويسنده ,
Abstract :
We developed a visible detection system for antibody-catalyzed retro-aldol-retro-Michael reactions. Aldolase antibody 38C2 catalyzed the reaction of substrate 1 to provide 6-bromo-2-napthol that forms a visible colored azo dye with diazonium salts. This system has potential for the screening of novel catalysts.
