Title of article
Novel synthesis and RNA-Binding properties of aminoglycoside dimers conjugated via a naphthalene diimide-based intercalator
Author/Authors
Jeffrey B. -H. Tok، نويسنده , , Jason Fenker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2987
To page
2991
Abstract
The synthesis and RNA-binding properties of naphthalene-based diimide conjugated bis-aminoglycoside antibiotics are reported. Compared to the monomeric aminoglycoside, the conjugated ligands were observed to attain up to 35-fold enhancement in binding affinity towards a novel RNA construct that contained two 16S rRNA A-sites.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791776
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