Author/Authors :
Cristina Chamorro، نويسنده , , Esther Lobat?n، نويسنده , , Mar?a-Cruz Bonache، نويسنده , , Erik De Clercq، نويسنده , , Jan Balzarini، نويسنده , , Sonsoles Vel?zquez، نويسنده , , Ana San-Félix، نويسنده , , Mar?a-José Camarasa، نويسنده ,
Abstract :
N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.
