Author/Authors :
Philip M. Warner، نويسنده , , Jiwei Qi، نويسنده , , Bin Meng، نويسنده , , Gang Li، نويسنده , , Longfei Xie، نويسنده , , Ahmed El-Shafey، نويسنده , , Graham B. Jones، نويسنده ,
Abstract :
A series of aryl amines was found to induce cleavage of DNA. Subsequent refinement led to an efficient family of dimeric derivatives capable of cleavage at low concentration. Initial investigations suggest this is an unprecedented mode of DNA cleavage, which may be ultimately applied to the development of sequence-specific agents.
