Author/Authors :
Simon J. A. Grove، نويسنده , , Jasmit Kaur، نويسنده , , Alan W. Muir، نويسنده , , Eleanor Pow، نويسنده , , Gary J. Tarver، نويسنده , , Mingqiang Zhang، نويسنده ,
Abstract :
A series of oxyanilinium-based AChE inhibitors have been synthesised and tested for the reversal of vecuronium-induced neuromuscular block. Several compounds, for example 2-hydroxy- and 2-methoxy-N,N-dimethyl-N-allylanilinium bromide (3 and 6) showed comparable reversal potencies to edrophonium and clean in vivo cardiovascular profiles.
