Title of article
3-Aryl pyridone derivatives. Potent and selective kappa opioid receptor agonists
Author/Authors
Graeme Semple، نويسنده , , Britt-Marie Andersson، نويسنده , , Vijay Chhajlani، نويسنده , , Jennie Georgsson، نويسنده , , Magnus Johansson، نويسنده , , Marcel Lindschoten، نويسنده , , Fritof Pontén، نويسنده , , Asa Rosenquist، نويسنده , , Henrik S?rensen، نويسنده , , Lars Swanson، نويسنده , , Marianne Swanson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
197
To page
200
Abstract
A new series of 3-aryl pyridone based kappa opioid receptor agonists was designed and synthesised, based on an understanding of the classical kappa opioid receptor pharmacophore. The most potent of the new compounds were comparable to U-69,593 in receptor affinity, selectivity and functional agonist effect at the cloned human kappa opioid receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791934
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