Author/Authors :
Hiromasa Kurosaki، نويسنده , , Aoi Maruyama، نويسنده , , Hiroyuki Koike، نويسنده , , Naoko Kuroda، نويسنده , , Yoshinobu Ishikawa، نويسنده , , Masafumi Goto، نويسنده ,
Abstract :
Four pentadentate iron(II) complexes containing non- or fluoro-substituted phenyl group (2b–2e) were synthesized and cleaving activity of them to pUC19 DNA was evaluated in the presence of hydrogen peroxide. DNA cleavage activity increased with the number of substituted fluorine atoms on the phenyl group of 2b.
