Author/Authors :
Klaus Urbahns، نويسنده , , Michael H?rter، نويسنده , , Markus Albers، نويسنده , , Delf Schmidt، نويسنده , , Beatrix Stelte-Ludwig، نويسنده , , Ulf Brüggemeier، نويسنده , , Andrea Vaupel، نويسنده , , Christoph Gerdes، نويسنده ,
Abstract :
Vitronectin receptor (αVβ3) antagonism has been implicated as a mechanism for the treatment of restenosis following balloon angioplasty. In this work we present results from screening of a focused combinatorial library based on a biphenyl moiety. Our SAR studies led to the identification of compounds with subnanomolar activity, selectivity towards the related GPIIbIIIa receptor and functional activity on human smooth muscle cell migration.
