Author/Authors :
Silvère Aubriot، نويسنده , , Edwige Nicolle، نويسنده , , Mireille Lattier، نويسنده , , Cécile Morel، نويسنده , , Wenhong Cao، نويسنده , , Kiefer W. Daniel، نويسنده , , Sheila Collins، نويسنده , , Gérard Leclerc، نويسنده , , Patrice Faure، نويسنده ,
Abstract :
A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the β3-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities.
