Title of article
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
Author/Authors
Chester A. Mathis، نويسنده , , Brian J. Bacskai، نويسنده , , Stephen T. Kajdasz، نويسنده , , Megan E. McLellan، نويسنده , , Matthew P. Frosch، نويسنده , , Bradley T. Hyman، نويسنده , , Daniel P. Holt، نويسنده , , Yanming Wang، نويسنده , , Guofeng Huang، نويسنده , , Manik L. Debnath، نويسنده , , William E. Klunk، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
295
To page
298
Abstract
The synthesis of a new lipophilic thioflavin-T analogue (2-[4′-(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [11C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [11C]6 is a promising amyloid imaging agent for Alzheimerʹs disease.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791957
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