Author/Authors :
Chester A. Mathis، نويسنده , , Brian J. Bacskai، نويسنده , , Stephen T. Kajdasz، نويسنده , , Megan E. McLellan، نويسنده , , Matthew P. Frosch، نويسنده , , Bradley T. Hyman، نويسنده , , Daniel P. Holt، نويسنده , , Yanming Wang، نويسنده , , Guofeng Huang، نويسنده , , Manik L. Debnath، نويسنده , , William E. Klunk، نويسنده ,
Abstract :
The synthesis of a new lipophilic thioflavin-T analogue (2-[4′-(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [11C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [11C]6 is a promising amyloid imaging agent for Alzheimerʹs disease.
