Title of article
Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha
Author/Authors
Hiroyuki Miyachi، نويسنده , , Masahiro Nomura، نويسنده , , Takahiro Tanase، نويسنده , , Masahiro Suzuki، نويسنده , , Koji Murakami، نويسنده , , Katsuya Awano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
333
To page
335
Abstract
Optically active phenylpropanoic acid derivatives [(S)-5, and (R)-5] were prepared, and their affinities for peroxisome proliferator-activated receptor (PPAR)α and PPARγ were evaluated. Binding assay and cell-based reporter assay indicated that the activity of these compounds is enantio-dependent, and resides exclusively on the (S)-isomer.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791966
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