Title of article :
Design, synthesis and biological activity of novel C2-C3′ N-Linked macrocyclic taxoids
Author/Authors :
Iwao Ojima، نويسنده , , Xudong Geng، نويسنده , , Songnian Lin، نويسنده , , Paula Pera، نويسنده , , Ralph J. Bernacki، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
A series of novel macrocyclic taxoids was designed and synthesized by connecting the C-2 and C-3′ N positions of the taxoid framework with various tethers. Cytotoxicity of these macrocyclic taxoids was evaluated against a human breast cancer cell line LCC6-WT, and a couple of the taxoids exhibited 0.09–0.3 μM IC50 values.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
