Author/Authors :
Nan Zhang، نويسنده , , Biqi Wu، نويسنده , , Allan Wissner، نويسنده , , Dennis W. Powell، نويسنده , , Sridhar K. Rabindran، نويسنده , , Constance Kohler، نويسنده , , Frank Boschelli، نويسنده ,
Abstract :
A series of 4-anilino-3-cyanobenzo[g]quinolines was prepared as potent kinase inhibitors. Compared with their bicyclic 4-anilino-3-cyanoquinoline analogues, the tricyclic 4-anilino-3-cyanobenzo[g]quinolines are less active against EGF-R kinase, equally active against MAPK kinase (MEK), and more active against Src kinase. For Src kinase inhibition, the best activity is obtained when both the 7- and 8-positions are substituted with alkoxy groups. Several of these kinase inhibitors show potent growth inhibitory activity in tumor cells.
