Title of article
Discovery of 5-Hydroxyalkyl-4-phenylpyridines as a New Class of Glucagon Receptor Antagonists
Author/Authors
Gaetan H. Ladouceur، نويسنده , , James H. Cook، نويسنده , , Elizabeth M. Doherty، نويسنده , , William R. Schoen، نويسنده , , Margit L. MacDougall، نويسنده , , James N. Livingston، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
461
To page
464
Abstract
5-Hydroxyalkyl-4-phenylpyridines have been identified as a novel class of glucagon antagonists with potential utility for the treatment of diabetes. A lead structure with moderate activity was discovered through a high throughput screening assay. Structure–activity relationships led to the discovery of a potent antagonist, IC50=0.11 μM, more than 60-fold improvement over the lead structure.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791996
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