Title of article
Synthesis and Anti-Angiogenic Activity of 6-(1,2,4-Thiadiazol-5-yl)-3-amino pyridazine Derivatives
Author/Authors
Jean-Pierre Bongartz، نويسنده , , Raymond Stokbroekx، نويسنده , , Marcel Van der Aa، نويسنده , , Marcel Luyckx، نويسنده , , Marc Willems، نويسنده , , Marc Ceusters، نويسنده , , Lieven Meerpoel، نويسنده , , Gerda Smets، نويسنده , , Tine Jansen، نويسنده , , Walter Wouters، نويسنده , , Charlie Bowden، نويسنده , , Lisa Valletta، نويسنده , , Mark Herb، نويسنده , , Rose Tominovich، نويسنده , , Robert Tuman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
589
To page
591
Abstract
General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally active compounds with potent in vitro and in vivo anti-angiogenesis and anti-tumor activities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792024
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