Author/Authors :
Satoshi Sunami، نويسنده , , Mitsuru Ohkubo، نويسنده , , Takeshi Sagara، نويسنده , , Jun Ono، نويسنده , , Shuichi Asahi، نويسنده , , Seita Koito، نويسنده , , Hajime Morishima، نويسنده ,
Abstract :
Replacement of the thiol groups in 1, a potent and highly selective Candida albicans GGTase I inhibitor discovered through screening, with an imidazole ring was achieved by using solid phase synthesis. A non-thiol compound, 7, was found as a representative of a new class of potent C. albicans GGTase I inhibitor with high selectivity against human GGTase I.
