Author/Authors :
Stephen E. de Laszlo، نويسنده , , Bing Li، نويسنده , , Ermengilda McCauley، نويسنده , , Gail Van Riper، نويسنده , , William K. Hagmann، نويسنده ,
Abstract :
A combinatorial library of 28 pools of 180 compounds (345 diastereomers) was designed and prepared in support of the delineation of the SAR of two prototypical VLA-4 antagonists. Deconvolution of the active pools led to the identification of three novel series of VLA-4 antagonists with low nanomolar potencies.
