Title of article
New indene-derivatives with anti-proliferative properties
Author/Authors
Ioanna-Maria Karaguni، نويسنده , , Karl-Heinz Glüsenkamp، نويسنده , , Anette Langerak، نويسنده , , Christoph Geisen، نويسنده , , Volker Ullrich، نويسنده , , Günther Winde، نويسنده , , Tarik M?r?y، نويسنده , , Oliver Müller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
709
To page
713
Abstract
Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792053
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