Title of article
Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 2: substituted benzo[a]cycloheptene derivatives
Author/Authors
Hiromichi Itani، نويسنده , , Harunobu Ito، نويسنده , , Yoshihiko Sakata، نويسنده , , Yoshifumi Hatakeyama، نويسنده , , Hiroko Oohashi، نويسنده , , Yoshinari Satoh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
757
To page
761
Abstract
Novel benzo[a]cycloheptene derivatives were prepared for the purpose of searching new neuropeptide Y-Y5 (NPY-Y5) receptor antagonists. The structure–activity relationships are described and compound 2o (FR226928) showed the most potent affinity for Y5 receptor of all we prepared and was found to have higher potency and better selectivity for Y5 over Y1 receptor affinities when compared with the known lead compound 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792062
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