Author/Authors :
Atul Goel، نويسنده , , Sharlyn J. Mazur، نويسنده , , Rasem J. Fattah، نويسنده , , Tracy L. Hartman، نويسنده , , Jim A. Turpin، نويسنده , , Mingjun Huang، نويسنده , , William G. Rice، نويسنده , , Ettore Appella، نويسنده , , John K. Inman، نويسنده ,
Abstract :
The HIV-1 nucleocapsid protein NCp7, which contains two highly conserved zinc fingers, is being used as a novel target for AIDS therapy due to its pivotal role in viral replication and its mutationally intolerant nature. Herein we report a new class of NCp7 inhibitors that possess good antiviral activity with low cellular toxicity.
