Author/Authors :
Stuart W. McCombie، نويسنده , , Sue-Ing Lin، نويسنده , , Jayaram R. Tagat، نويسنده , , Dennis Nazareno، نويسنده , , Susan Vice، نويسنده , , Jennifer Ford، نويسنده , , Theodros Asberom، نويسنده , , Daria Leone، نويسنده , , Joseph A. Kozlowski، نويسنده , , Guowei Zhou، نويسنده , , Vilma B. Ruperto، نويسنده , , Ruth A. Duffy، نويسنده , , Jean E. Lachowicz، نويسنده ,
Abstract :
The synthesis and muscarinic binding properties of compounds based on the 1-[4-(4-arylsulfonyl)phenylmethyl]-4-(1-aroyl-4-piperidinyl)-piperazine skeleton are described. For compounds, substituted with appropriately configured methyl groups at the benzylic center and at the piperazine 2-position, high levels of selective, M2 subtype affinity could be obtained, particularly when the terminal N-aroyl residue was ortho-substituted.
