Hydrophobic modifications at 1-phosphate of inositol 1,4,5-Trisphosphate analogues enhance receptor binding

Inositol 1,4,5-trisphosphate (IP3) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP3 for strong binding to the IP3 receptor. Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure.