Title of article
Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors
Author/Authors
Ao Zhang، نويسنده , , Guochun Zhou، نويسنده , , Suo-Bao Rong، نويسنده , , Kenneth M. Johnson، نويسنده , , Mei Zhang، نويسنده , , Alan P. Kozikowski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
993
To page
995
Abstract
A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.03,7]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792119
Link To Document