Title of article :
A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production
Author/Authors :
Tadashi Honda، نويسنده , , Yukiko Honda، نويسنده , , Frank G. Favaloro Jr.، نويسنده , , Gordon W. Gribble، نويسنده , , Nanjoo Suh، نويسنده , , Andrew E. Place، نويسنده , , Mara H. Rendi، نويسنده , , Michael B. Sporn، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
New oleanane triterpenoids with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and methyl 2-carboxy-3,12-dioxooleana-1,9(11)-dien-28-oate were synthesized. Among them, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile shows extremely high inhibitory activity (IC50=1 pM level) against production of nitric oxide induced by interferon-γ in mouse macrophages. This potency is about 100 times and 30 times more potent than CDDO and dexamethasone, respectively.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
