Author/Authors :
Yuguang Wang، نويسنده , , Samuel Chackalamannil، نويسنده , , Zhiyong Hu، نويسنده , , Brian A. McKittrick، نويسنده , , William Greenlee، نويسنده , , Vilma Ruperto، نويسنده , , Ruth A. Duffy، نويسنده , , Jean E. Lachowicz، نويسنده ,
Abstract :
We have discovered highly potent, selective sulfide M2 receptor antagonists with low molecular weight and different structural features compared with our phase I clinical candidate Sch 211803. Analogue 30 showed superior M2 receptor selectivity profile over Sch 211803. More importantly, this study provided new leads for the discovery of M2 receptor antagonists as potential drug candidates.
