Author/Authors :
Randy W. Jackson، نويسنده , , Richard Gelinas، نويسنده , , Ted A. Baughman، نويسنده , , J. Thomas Cox، نويسنده , , J. Jeffry Howbert، نويسنده , , Kristin A. Kucera، نويسنده , , John A. Latham، نويسنده , , Fred Ramsdell، نويسنده , , Devinder Singh ، نويسنده , , Ihab S. Darwish، نويسنده ,
Abstract :
A novel series of TNF-α inhibitors based on a benzobicyclooctane scaffold is reported. The compounds display good potency in inhibiting TNF-α induced apoptosis and NFκB activation. Additionally, they are selective for TNF-α as they do not inhibit apoptosis induced by soluble Fas ligand. The compounds described here can act as leads for future medicinal chemistry efforts and may also be useful tools for elucidating the TNF-α signaling pathway.
