Author/Authors :
Sharon M. Dankwardt، نويسنده , , Sarah C. Abbot، نويسنده , , Chris A. Broka، نويسنده , , Robert L. Martin، نويسنده , , Christine S. Chan، نويسنده , , Eric B. Springman، نويسنده , , Harold E. Van Wart، نويسنده , , Keith A. M. Walker، نويسنده ,
Abstract :
Optimization of the amino acid side chain and the N-alkyl group of the sulfonamide of amino acid derived sulfonamide hydroxamates is discussed. The solid-phase synthesis of these potent inhibitors of procollagen C-proteinase (PCP) is presented. In addition, novel carboxylic acid sulfonamides were discovered to be PCP inhibitors.
