Author/Authors :
Mark R. Burns، نويسنده , , Solveig LaTurner، نويسنده , , Josh Ziemer، نويسنده , , Maralee McVean، نويسنده , , Bruce Devens، نويسنده , , C. Lance Carlson، نويسنده , , Gerard F. Graminski، نويسنده , , Scott M. Vanderwerf، نويسنده , , Reitha S. Weeks، نويسنده , , Jay Carreon، نويسنده ,
Abstract :
A series of aromatic substituted diamines was synthesized and characterized for their cytotoxic profiles against human breast and prostate tumor cell lines. Following a structure function analysis of the effects of changes of the benzyl substituents and the distance between amino groups the most potent analogues were analyzed biologically and were shown to induce apoptosis. These compounds do not induce the enzyme SSAT or deplete intracellular polyamine levels, mechanisms demonstrated by other cytotoxic polyamine analogues.
