Title of article
Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands
Author/Authors
Mi Young Cha، نويسنده , , Byung Chul Choi، نويسنده , , Kyung Ho Kang، نويسنده , , Ae Nim Pae، نويسنده , , Kung Il Choi، نويسنده , , Yong Seo Cho، نويسنده , , Hun Yeong Koh، نويسنده , , Hee-Yoon Lee، نويسنده , , Daeyoung Jung، نويسنده , , Jae Yang Kong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1327
To page
1330
Abstract
A piperazinylbutylisoxazole libary was designed, synthesized and screened for the binding affinities to dopamine D2, D3, and D4 receptors. Several ligands were identified to possess high binding affinity and selectivity for the D3 and D4 receptors over the D2 receptor. Compounds 6s and 6t showed Ki values of 2.6 nM and 3.9 nM for the D3 receptor with 46- and 50-fold selectivity over the D2 receptor, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792208
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