Title of article
Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group
Author/Authors
Shinichi Uesato، نويسنده , , Manabu Kitagawa، نويسنده , , Yasuo Nagaoka، نويسنده , , Taishi Maeda، نويسنده , , Hiroshi Kuwajima، نويسنده , , Takao Yamori، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
1347
To page
1349
Abstract
Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792213
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