Author/Authors :
Margaret Y. Chu-Moyer، نويسنده , , William E. Ballinger، نويسنده , , David A. Beebe، نويسنده , , James B. Coutcher، نويسنده , , Wesley W. Day، نويسنده , , Jiancheng Li، نويسنده , , Peter J. Oates، نويسنده , , R. Matthew Weekly، نويسنده ,
Abstract :
SAR studies on the stereoisomers of CP-470,711 suggested that in vivo epimerization was taking place in rats. Further metabolism studies revealed that no epimerization was occurring in dogs, and that no epimerization was expected in humans. A mechanism for the in vivo epimerization is proposed involving an oxidation–reduction pathway of the secondary benzylic alcohol, in contrast to an acid/base-promoted epimerization of the same center during chemical synthesis.
