Title of article
9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase[]
Author/Authors
Mohamed Brakta، نويسنده , , Devangachinta Murthy، نويسنده , , LʹOuverture Ellis، نويسنده , , Shashikant Phadtare، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1489
To page
1492
Abstract
New phenyl adenine compounds 5–7 were synthesized as analogues of adenosine and studied for their adenosine deaminase (ADA) substrate activity. The 9-[(o-hydroxymethyl)phenyl]methyl]adenine 5 and 9-[(m-hydroxymethyl)phenyl]adenine 7 were deaminated by ADA, and 9-[(o-hydroxyethyl)phenyl]adenine 6 was not deaminated up to 7 days. The ADA substrates 5 and 7 were deaminated quantitatively to their inosine analogues in 10 and 6 h, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792244
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