Author/Authors :
L?dia M. Lima، نويسنده , , Fernanda C. F. de Brito، نويسنده , , Simone D. de Souza، نويسنده , , Ana L. P. Miranda، نويسنده , , Carlos R. Rodrigues، نويسنده , , Carlos A. M. Fraga، نويسنده , , Eliezer J. Barreiro، نويسنده ,
Abstract :
A series of phthalimide acid derivatives was synthesized and evaluated as leukotriene D4 receptor antagonists. The tetrazolephthalimide LASSBio 552 (7) was shown to be able to inhibit the contractile activity induced by 100 nM of LTD4 in guinea-pig tracheal strips with an IC50=31.2 μM. In addition, LASSBio 552 (7) has been showed to present a better efficacy than zafirlukast (1) used as standard.
