Title of article
Novel phthalimide derivatives, designed as leukotriene D4 receptor antagonists
Author/Authors
L?dia M. Lima، نويسنده , , Fernanda C. F. de Brito، نويسنده , , Simone D. de Souza، نويسنده , , Ana L. P. Miranda، نويسنده , , Carlos R. Rodrigues، نويسنده , , Carlos A. M. Fraga، نويسنده , , Eliezer J. Barreiro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
1533
To page
1535
Abstract
A series of phthalimide acid derivatives was synthesized and evaluated as leukotriene D4 receptor antagonists. The tetrazolephthalimide LASSBio 552 (7) was shown to be able to inhibit the contractile activity induced by 100 nM of LTD4 in guinea-pig tracheal strips with an IC50=31.2 μM. In addition, LASSBio 552 (7) has been showed to present a better efficacy than zafirlukast (1) used as standard.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792254
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