Title of article
Exploration of peptidyl hydrazones as water-soluble calpain inhibitors
Author/Authors
Masayuki Nakamura، نويسنده , , Jun Inoue، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1603
To page
1606
Abstract
A series of peptidyl hydrazones was synthesized, and their inhibitory activity against μ-calpain and water-solubility were measured. Among these compounds, N,N-dimethyl glycyl hydrazone 6, which inhibited μ-calpain with IC50 of 0.37 μM, possessed the appropriate water-solubility. Furthermore, hydrazone 6 was found to possess the excellent in vitro metabolic stability.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792270
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