Title of article
Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability
Author/Authors
Alan D. Borthwick، نويسنده , , Anne M. Exall، نويسنده , , Terry M. Haley، نويسنده , , Deborah L. Jackson، نويسنده , , Andrew M. Mason، نويسنده , , Gordon G. Weingarten، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1719
To page
1722
Abstract
Mechanism-based inhibitors of HCMV protease, which are stable to human plasma (≥20 h) and have single-figure potency in the μM range against HCMV protease, have been developed based on the dansylproline α-methyl pyrrolidine-5,5-trans-lactam nucleus.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792297
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