Title of article
4,4-Disubstituted cyclohexylamine NK1 receptor antagonists I
Author/Authors
Jason M. Elliott، نويسنده , , José L. Castro، نويسنده , , Gary G. Chicchi، نويسنده , , Laura C. Cooper، نويسنده , , Kevin Dinnell، نويسنده , , Gregory J. Hollingworth، نويسنده , , Mark P. Ridgill، نويسنده , , Wayne Rycroft، نويسنده , , Marc M. Kurtz، نويسنده , , Duncan E. Shaw، نويسنده , , Christopher J. Swain، نويسنده , , Kwei-Lan Tsao، نويسنده , , Lihu Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1755
To page
1758
Abstract
A series of novel 4,4-disubstituted cyclohexylamine based NK1 antagonists is described. The effect of changes to the C1–C4 relative stereochemistry on the cyclohexane ring and replacements for the flexible linker are discussed, leading to the identification of compounds with high affinity and good in vivo duration of action.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792306
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