Title of article
Discovery of non-Zwitterionic GABAA receptor full agonists and a superagonist
Author/Authors
Paul R. Carlier، نويسنده , , Ella S. -H. Chow، نويسنده , , Rebecca L. Barlow، نويسنده , , Jeffrey R. Bloomquist، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1985
To page
1988
Abstract
Numerous previous studies of GABAA receptor ligands have suggested that GABAA receptor agonists must be zwitterionic and feature an intercharge separation similar to that of GABA (approx. 4.7–6 Å). In this communication we demonstrate that appropriately functionalized GABA amides are partial, full, or superagonists, despite their non-zwitterionic structure.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792358
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