Title of article
Novel cyclourethane-Derived HIV protease inhibitors: A ring-closing olefin metathesis based strategy
Author/Authors
Arun K. Ghosh، نويسنده , , Lisa M. Swanson، نويسنده , , Chunfeng Liu، نويسنده , , Khaja Azhar Hussain، نويسنده , , Hanna Cho، نويسنده , , D. Eric Walters، نويسنده , , Louis Holland، نويسنده , , Jim Buthod، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1993
To page
1996
Abstract
A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against HIV-1 protease.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792360
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