Author/Authors :
Midori Itoh، نويسنده , , Jun Kuwahara، نويسنده , , Kohji Itoh، نويسنده , , Yu-ichi Fukuda، نويسنده , , Mikiko Kohya، نويسنده , , Mitsuru Shindo، نويسنده , , Kozo Shishido، نويسنده ,
Abstract :
Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.
